Methylene Blue and Muscle Hypertrophy
Does methylene blue have an impact on human muscle size? Methylene blue has been largely established as safe to use in humans but does it have a negative effect on muscle size? This may be important as muscle is the largest metabolic organ we have and plays an important part in glucose regulation. Thus, muscle mass plays a role in keeping glucose and insulin levels in check which keeps us insulin sensitive. Study: Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults, PMID: 23220477 This study look at the effect of taking paracetamol or ibuprofen while resistance training in an elderly population. They found that the drugs (common anti-inflammatories) actually promoted muscle mass and strength gains. "The drug-induced suppression of intramuscular PGE2 production increased net muscle protein balance after each exercise bout through a reduction in PGE2-induced IL-6 and ...